NSCI436 Study Guide - Midterm Guide: Quantitative Trait Locus, Knockout Mouse, Glucocorticoid Receptor
27 Oct 2016
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2 examples of non-mendelian inheritance: genomic imprinting: the phenotypic effects of some genes depend on whether they were inherited from the mother or father less than 1% of genes are imprinted. Igf2 gene: genes from mom (off), genes from dad (on: beckwith-wiedemann syndrome. Breeding in mules: female horse + male donkey = mule, female donkey + male horse = hinny. Prader-willi: intellectual and developmental delay, obesity. Deletion/inactivation of segment of paternal chromosome 15. Angelman syndromes: intellectual and developmental delay, seizures, jerky movements, frequent laughter and happy demeanor. Mitochondrial inheritance: entirely through the mother, dysfunctional cellular energy metabolism emerging as having a role in psychiatric disorders, mitochondrial dna replication is prone to error, which leads to many mitochondrial diseases and perhaps psychiatric disorders. Keys terms/concepts from our molecular biology lesson regarding how you get from dna to gene expression. Genome: the complete set of genes or genetic material present in a cell or organism.
