MCB 252 Study Guide - Midterm Guide: Tata-Binding Protein, Tata Box, Dna Binding Site

• School: University of Illinois
• Department: Molecular and Cell Biology
• Course: MCB 252
• Professor: Rivier David

Document Summary

Study online at quizlet. com/_20ay7w: 2 types of coactivators, 26s proteasome. -found in both the cytoplasm and the nucleus. This is symmetrical, with 7 and 7 subunits. The subunits are adjacent to the caps, and the subunits are internal. In eukaryotic proteasomes, only 3 of the 7 subunits are catalytically active. The other 4 subunits participate in substate binding. This is why the 26s proteasome can degrade virtually any protein: because its proteases have a wide spectrum of substrates. Composed of 10 subunits and has a molecular mass of ~700 kda (19s proteasome also named. Pa700 recognizes polyubiquitonated proteins to be degraded, hydrolizes atp to open up the. Pa700). channel, and controls axis to the core particle. -uses atp to unfold the target protein and feed it into the chamber as a linear polypeptide sequence (n terminus first) -the proteolysis of the polypeptide substrate is processive and consists in successive cleavages starting near the n terminus.