PSYCH 111 Study Guide - Midterm Guide: Free Base, Ephedrine, Cocaethylene
Document Summary
Mechanisms base structure = phenylethylamine (structurally similar to catecholamine nts) *increase synaptic concentrations of: monoamine nt"s (da, ne, e, 5-ht) 1st uses: decongestant/asthma, narcolepsy, diet pills (no longer allowed) Add/adhd amphetamine = racemic (r+l) d-amphetamine = r/d l-amphetamine = less potent methamphetamine = dl-methyl . *usually pills pills (po) synthetic (ephedrine is amph-like, comes from plant; khat contains cathinone, chew leaves) Vmat on (vesicles), membrane transporters: dat, net, sert. Ca2+ independent; not blocked by reserpine; blocked by ampt (which also blocks. Th+synthesis); metabolites decrease, even though da increases; thought to be transported into terminal through dat; Dat may push da back into cleft (from cytosolic pool) Higher doses: may transport amph. into vesicles and move da into cytosol major metabolite = benzoylecgonine (inactive) active metabolite cocaethylene is formed when cocaine is taken with alcohol. Ht/serotonin) local anesthetic (most local anesthetics come from cocaine, i. e. lidocaine) paste (mainly in south america), raw leaves to chew or make tea;
