BIOLOGY 285 Study Guide - Midterm Guide: Long Non-Coding Rna, Operon, Activation Energy
16 Nov 2020
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Ligand anything that interacts with protein: protein binding pocket (lock and key method, protein surface, noncovalent bonds between interactions weaker bonds so they can break apart easily, van der waals / hydrophobic, hydrogen. If nonpolar r was changed to polar r, binding differences. (r group chemistry and give specific examples) If positively charged r was changed to negatively charged r, the amino acids will repel. It is this surface structure that determines which substrates the protein will be interacting with. Thus, by being able to change each individual protein in a variety of different ways through post-translational modifications, a single protein can bind with a whole variety of different substrates: addition of nucleotides to proteins activate protein. Importin binds to the cargo protein on the nuclear localization site and moves into the nucleus: gef removes gdp and adds gtp to ran.
