NURS 3518 Study Guide - Midterm Guide: Superoxide Dismutase, Glutathione Peroxidase, Lipid Peroxidation
25 Jun 2019
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Also, less atp causes more anaerobic glycolysis more lactate and lower ph nuclear chromatin clumping less protein synthesis. Complication post-transplant, mi, stroke, renal/hepatic cells: oxidative stress when re-oxygenation causes excess ros/free radicals overwhelm the body"s antioxidant system ros and free radicals cause membrane damage and mitochondrial ca overload. Neutrophil adhesion to endothelium can be reversed by antioxidant treatment. Ros are highly reactive and have low specificity. Neutralize them, stop chain reaction: chemical direct toxicity: cyanide inhibits mitochondrial oxidase and blocks electron transport. Infectious microorganisms invade, destroy, produce toxins, cause allergic reactions. Also, too much protein pushes against other organelles, disrupting fx and communication: hemoproteins essential normal pigments, include hemoglobin, cytochromes. Accum due to excessive iron storage (hemosiderosis), lead to liver/pancreatic cell damage: ca++ influx occurs in injured mito. Cells digested by own hydrolases, so tissue is soft, separates from healthy tissue, occurs in brain: coagulative occurs in heart, kidney, adrenal glands from hypoxia.
