MATH 241 Quiz: MATH 241 UPenn Solution to Quiz 2
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Questions from jeff smith (50 pts. total: your lab studies a species of pathogenic bacteria. You have identified a new gene that encodes a protein with significant similarity to the gcn5 histone acetyltransferase from yeast. Based on an amino acid alignment with other hats you believe that arg124, glu135, and ala140 would be positioned near the active site. You plan on mutating each of these amino acids individually to determine if they were required for hat activity. Which of the three mutations would you expect to most likely cause a complete loss of activity, and why? (5 pts) Bims 503 exam 4: draw the following chemical structures: a) unmodified lysine amino acid. b) acetylated lysine. c) mono-methylated lysine. In each case, be sure to indicate the charge status of the lysine (5 pts): what are the donor molecules for the following post-translational modifications? (5 pts, acetylation.
