LQB185 Chapter Notes - Chapter 18: Exocrine Gland, Pineal Gland, Extracellular Fluid

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Chapter 18- Endocrine System
18.1 Comparison of Control by the Nervous and Endocrine System
➢ Like the nervous system (nervous system has nerve impulses that trigger
a release of a mediatory called neurotransmitter) the endocrine system
also control body activates by releasing mediators called hormones.
➢ Hormone- molecule that is released into the body via interstitial fluid
then bloodstream.
➢ The endocrine system keeps levels of consciousness and cognition +
protection and regulation.
18.2 Endocrine Glands
➢ Exocrine Glands- (outside) secrete products into ducts into outer surface
of body and contain sweat, oil and mucous.
➢ Endocrine Glands- (inside) secrete products into the interstitial fluid
surrounding cells.
➢ Endocrine Glands include:
➢ Pituitary
➢ Thyroid
➢ Parathyroid
➢ Adrenal
➢ Pineal Glands
➢ All the endocrine glands + hormone-secreting cells make up the
Endocrine System.
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18.3 Hormone Activity
➢ Hormones influence their targeted cells by chemically binding with
specific protein receptors
➢ Only targeted cells for a specific hormone can bind and recognise it. (e.g.
thyroid-stimulating hormone binds with cells of the thyroid gland)
➢ Down-regulation- Target cells have 2000-100000 receptors, if the
hormone is present in excess, the number of target cell receptors
decreases. THUS, the cell becomes less sensitive to a hormone
➢ Up-regulation- if the hormone is deficient, the number of target cell
receptors increases. THUS, target cell is more sensitive.
➢ Circulating Hormones- pass from the secretory cell that made them into
interstitial fluid and then the bloody stream.
➢ Local Hormones- act locally on neighbouring cells or on the same cell
that made them.
➢ Paracrine (beside or near)
- hormones that act on neighbouring cells
➢ Autocrine (self)
- hormones that act on the same cell that secreted them
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➢ Classification of Hormones
➢ Lipid-Soluble Hormones
1. Steroid Hormones- derided from cholesterol. All are unique
given the presents of different chemical groups for various
sites.
2. Two Thyroid Hormones (T3 + T4)- are synthesised by
attaching iodine to the amino acid tyrosine. Them together
makes the molecule very lipid-soluble.
3. Gas Nitric Oxide (NO)- is a hormone and a
neurotransmitter.
➢ Water-Soluble Hormones
1. Amine Hormones- synthesised by decarboxylating
(removing a molecule of CO2) and modifying certain amino
acids.
2. Peptide Hormones/Protein Hormones- are amino acid
polymers. Contain chains of amino acids.
3. Eicosanoid Hormones- derived from arachidonids. Two
types Prostaglandins (PGs) and Leukotrienes (LTs).
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Document Summary

18. 1 comparison of control by the nervous and endocrine system. Like the nervous system (nervous system has nerve impulses that trigger a release of a mediatory called neurotransmitter) the endocrine system also control body activates by releasing mediators called hormones. Hormone- molecule that is released into the body via interstitial fluid then bloodstream. The endocrine system keeps levels of consciousness and cognition + protection and regulation. Exocrine glands- (outside) secrete products into ducts into outer surface of body and contain sweat, oil and mucous. Endocrine glands- (inside) secrete products into the interstitial fluid surrounding cells. All the endocrine glands + hormone-secreting cells make up the. Hormones influence their targeted cells by chemically binding with specific protein receptors. Only targeted cells for a specific hormone can bind and recognise it. (e. g. thyroid-stimulating hormone binds with cells of the thyroid gland) Down-regulation- target cells have 2000-100000 receptors, if the hormone is present in excess, the number of target cell receptors decreases.

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