Textbook Notes (368,089)
Canada (161,636)
Chemistry (31)
CHEM 1004 (13)
Chapter 5

Chapter 5

2 Pages
121 Views
Unlock Document

Department
Chemistry
Course
CHEM 1004
Professor
Gerald Buchanan
Semester
Fall

Description
Chapter 5 - Drugs at the Synapse ● Synapse - The free space between neurons. Two Types: ○ Sensory - Information Gathering ○ Motor Neurons - Involved in movement or muscle activity ● At the synapse neurotransmitters are released from the end of one neuron into the free space, they diffuse across and bind to the receptor site (structure specific; lock and key).This causes a signal to be produced and a physiological effect ● Composition of Neurons: ○ Dendrites - Collect information ○ Cell Body - Processes it ○ Axons - Conduct the impulse to the next cell. (Nerve impulses only move in one direction) ● Ganglions - Collections of nerve cells and synapses concentrated in one location for easy interconnection and crossover ○ Preganglionic fibres lead up to the ganglion and postganglionic nerve fibres lead impulses away from the ganglion ● Transmissions are terminated when there is an enzymatic reaction of the transmitter molecule or with the expenditure of energy to release it from its binding point ● 6 Important neurotransmitters: = 2 really important ○ Acetylcholine - The transmitter in nerves that slow the heart, control the use of voluntary muscles, constrict involuntary muscle, and keep central nervous system working ■ Does not circulate in blood and is preganglionic ○ Epinephrine (adrenaline) and Norepinephrine - Both neurotransmitters but epinephrine is effective at lower concentrations ■ Norepinephrine (noradrenaline) - Released to stimulate heart contractions. It is a very powerful stimulant which increases heart rate and blood flow. It is postganglionic and opposite to acetylcholine ■ Receptors - Alpha ease breathing and beta cause an increase in heart activity when stimulated ■ “Beta Blockers” - block beta receptors and treat high blood pressure, chest pains, rapid heart rate ○ GABA (gamma-amino butyric acid) - is a major inhibitory transmitter in the brain accounting for ~33% of cerebral transmissions. Many drugs that cause its release act as relaxants, antispasmodics and antianxiety (such as Valium; a tranquilizer) ○ Serotonin - In human blood, brain and GI tract. Release of serotonin results in painkilling, sleepiness and changes in appetite ■ SSRI’s (Selective Serotonin Reuptake[means Keeps in synapse] Inhibitors) increase th
More Less

Related notes for CHEM 1004

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit