BCHM 316 Chapter Notes - Chapter 12-1B : G Protein–Coupled Receptor, Autocrine Signalling, Paracrine Signalling

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11 May 2018

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Types of receptors

1. G protein coupled receptors

2. Receptor enzymes

3. Gated ion channels

4. Nuclear receptors

- There are about 1000 g-protein coupled receptors in human genome

- Hormone is usually peptide, but occasionally small molecule

- Produce different second messengers to transduce biological effects in target cells

There are three types of signaling

Autocrine paracrine and endocrine

Autocrine: released by cell and act on same cell

Paracrine: released into extracellular space and act locally on neighboring cells

Endocrine: released in blood, binds to target cell which is some distance from the site of

synthesis

ADVANTAGES OF THE DIFF SIGNALLING

SIGNALS THAT TRIGGER HORMONE RELEASE

- Neuronal signals

- Blood solute signals

- Hypothalamic- pituitary endocrine gland axis

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