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Chapter 12-1B

BCHM 316 Chapter Notes - Chapter 12-1B : G Protein–Coupled Receptor, Autocrine Signalling, Paracrine Signalling


Department
Biochemistry
Course Code
BCHM 316
Professor
Glenville Jones
Chapter
12-1B

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Types of receptors
1. G protein coupled receptors
2. Receptor enzymes
3. Gated ion channels
4. Nuclear receptors
- There are about 1000 g-protein coupled receptors in human genome
- Hormone is usually peptide, but occasionally small molecule
- Produce different second messengers to transduce biological effects in target cells
There are three types of signaling
Autocrine paracrine and endocrine
Autocrine: released by cell and act on same cell
Paracrine: released into extracellular space and act locally on neighboring cells
Endocrine: released in blood, binds to target cell which is some distance from the site of
synthesis
ADVANTAGES OF THE DIFF SIGNALLING
SIGNALS THAT TRIGGER HORMONE RELEASE
- Neuronal signals
- Blood solute signals
- Hypothalamic- pituitary endocrine gland axis
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