Release enzyme to external environment via ducts. Examples: sudoriferous (sweat, sebaceous (oil, mucous, digestive. Release hormones directly into the blood stream. The pancreas acts as both an exocrine and endocrine gland. It is exocrine because it releases digestive enzymes through the pancreatic duct. It is endocrine because it releases insulin and glucagon directly into the blood. After a hormone is released from an endocrine gland it may take seconds to days for the hormone to exert its effect. The receptor is highly specific to a particular hormone. One method of hormone regulation is the reduction or increase of a receptor type in the presence of high or low concentrations of its hormone. There are hormones that have receptors on nearly all cells. There are also hormone that have receptors only on specific tissues. Even super low concentration of hormones in the blood can have a significant (noticeable) effect on the body.