PSYC 375 Chapter Notes - Chapter 6: Opioid Use Disorder, Tricyclic Antidepressant, Endothelium

• School: University of Calgary
• Department: Psychology
• Course: PSYC 375
• Professor: Simon Spanswick

Document Summary

Adhd drugs (impulsivity, hyperactivity, inattention) stimulates da release, block reuptake (like cocaine) learning at synapse through habituation and sensitization. :( side effects: sleep disruption, loss of appetite, headaches, cardiovascular abnormalities, addiction. Psychopharmacology study of how drugs affect ns and behaviour psychoactive drugs: substance that acts to alter mood, thought, behaviour; used to manage neuropsychological illness; or abused. Routes of administration: oral: safe, easy and convenient; most complex route should be water soluble to enter bloodstream. 10micrograms injected into csf, 1microgram injected directly onto target neurons) Molecules cross bbb in two ways: small molecules (o2, co2) pass through endothelial membrane, molecules of glucose, aa"s, other food components carried across by active- transport systems/ion pumps. [medically injected into muscle to block muscular twitches, spasms (cerebral palsy] [cosmetic use to paralyzed facial muscles that cause wrinkling] curare (blocks receptors) (skeletal muscles, can"t pass through bbb) Tolerance - decrease in response to a drug with the passage of time (resembles habituation)