CHEM237 Chapter Notes - Chapter 7: Pyrrole, Chemical Polarity, Nfkb1

• School: University of Waterloo
• Department: Chemistry
• Course: CHEM237
• Professor: Joseph Guillemette

Document Summary

Myoglobin: monomeric o2 binging protein, 153 aa folded into 8 helicies, 1 heme group in the centre. Facilitates o2 diffusion in muscle, but is not required for o2 transport. Myoglobin-o2 binding curve is hyperbolic, with a p50 of 1-2 torr. Heme: heterocyclic tetra pyrole linked by methyl bridges, open on 6th side for o2, stores o2 in muscles. P50 = pressure when 50% binding sites are occupied. Hill coef cient: slope of graph of (log yo2/ 1-yo2) vs ppo2, hill coef cient greater than 1 indicates a cooperative system. Hemoglobin: tetramer with 2 alpha and 2 beta subunits. Each subunit is homologous w/ myoglobin but not identical. Oxygen binding curve is sigmoidal, indicating cooperative binding (hb af nity for o2 increases with each o2 that binds) Function: transports o2 from the lungs to muscles, transports co2, h+ and no throughout the body.