MICB 202 Chapter Notes - Chapter Virology, HIV: Window Period, Fluorophore, Acrylamide
Document Summary
Case study #3: hiv example of a retrovirus. Picovirus: important human and animal pathogens with unusual replication cycle: interactions range from completely benign caused by endogenous viruses to fatal consequences (hiv) to cancer. Insert their genome into host cell"s chromosomes allows their genome to be transmitted to both progeny cells when the infected host divides: serious consequences. Host cell"s genetic sequence modified, and specific host genes can be activated or inactivated which can result in variety of pathological effects. Divided into 7 genera based on pathogenicity, nucleotide sequence, genome structures. Aids: makes victims susceptible to opportunistic pathogens. Characterized by occurrence of kaposi"s sarcoma or b cell lymphoma. Longer average time from initial infection to disease for hiv-2 than hiv-1. 4 limitations host imposes limitations on viral replication: hiv is an rna virus and host doesn"t have an enzyme that can read of synthesize rna. Encodes its own rddp: virus"s rddp needs a primer.
