BIOA01H3 Chapter Notes - Chapter 3-4.1: Tata Box, Sigma Factor, Ribonucleoside
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BIOA01H3 Full Course Notes
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Lecture 3: chapter 3 (3. 3 3. 4), chapter 4 (4. 1) Rna is a polymer of nucleotides linked by phosphodiester bonds like dna sugar is ribose sugar (cid:449)/ (cid:1006)(cid:859) oh (cid:894)(cid:373)ore rea(cid:272)ti(cid:448)e(cid:895) Uracil replaces thymine typically, smaller than dna molecules. One strand of dna is used a template for rna transcript that is complimentary to it (mrna) rna polymerase carried out the polymerization (cid:894)adds to the (cid:1007)(cid:859) e(cid:374)d(cid:895) Non-template strand is not transcribed transcription starts at the promoter sequences tata box /// stops at terminator sequence. Transcription of specific strand differs from gene to gene. House-keeping genes are transcribed all the time (vital to cell function) Bacteria promoter recognition is mediated by protein sigma factor. Promotor recognition in eukaryotes is more complicated than bacteria transcription requires the general transcription factors (group of proteins) (gtfs) Assembly of gtfs is required for transcription assemble on the promotor. Also need transcriptional activator protein binds to specific dna sequence called enhancer.
