MICR 303 Chapter Notes - Chapter 1: Polyethylene Glycol, Streptococcus Pneumoniae, Herd Immunity
6 Apr 2016
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Micr 303 study guide 2: describe the main steps in humoral immune response, e. g. , cells involved, activation mechanisms, lymphoid tissue structure and function, somatic hypermutation, class switch, etc. Relate this to the primary and secondary responses. See picture: describe basics of signal transduction, understand basics of mucosal immunity. Mouse plasma cells + myeloma cells (cancerous plasma cells) added together with polyethylene glycol to make cells that can divide indefinitely making the monoclonal antibody of interest: describe cell-mediated immunity. See picture: characterize immune response to thymus-independent antigens. Thymus independent antigens are antigens that stimulate b-cell activation without the help from a. They are made up of polysaccharides and polysaccharide derivatives, therefore have lots of repeating structures. Because there are so many antigens close together from the repeating structure, clusters of b-cells occur. This cluster makes a strong enough signal for the b- cell to be activated. Primary response and mostly only igm antibodies produced.
