Biology 1002B Chapter Notes - Chapter Outcomes: Tumor Suppressor Gene, Oncogene, Microrna
2 May 2019
School
Department
Course
Professor
Document Summary
Reasons why identical twins may have different cancer incidence. Can"t explain variation in cancer phenotype by knowing the genome of people. Reasons why cancer mortality varies across geographical areas in canada. Role of proto-oncogenes, tumor suppressor genes and oncomirs in normal organismal metabolism/development. Tumor suppressor genes -> maintains checks point at the end of g1. Making sure that those cells have repair all damages before they progress. Specifically targets mrnas to prevent them from coding specific protein. Mechanisms by which a virus could cause cancer without causing mutation. Could be disrupting one of the networks by upsetting the balance between oncogenes and tumor suppressor genes. Maybe messes with the epigenetic marks by bringing in a methylase. Maybe brings protein that messes up translation messages. General role of cyclin/cdk complexes in regulation of cell cycle checkpoints (not the specific. Posttranslation modification that affects the activity of targeted protein.
