BI110 Chapter Notes - Chapter 4: Peptide, Release Factor, Sigma Factor

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11 Dec 2017
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The central dogma: describes the process of transcription and translation, by which information in genes ow into proteins: dna - rna - protein. Peptide bonds hold amino acid groups together. Protein roles: building blocks for growth/ maintenance, provide energy, enzymes, transporters, antibodies, some hormones. Protein structure: primary: the sequence of amino acids, secondary: results from interactions of nearby amino acids, tertiary: three dimensional shape of polypeptides, quaternary: results from interactions of polypeptide subunits. Hydrophobic amino acids: aggregate (combine) together away from water, tend to be buried in the interior of folded proteins. Hydrophilic amino acids: interact with each other or with water via hydrogen bonding, tend to be on outside of folded proteins. Hydrophilic: each carbonyl group in the backbone forms a hydrogen bond with an amide group four residues away. Denatured(unfolded) proteins lose their function: some can be refolded under optimal conditions and regain function. Translation: dna rna protein transcription translation, components for translation.

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