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BIOL 2021 Chapter Notes - Chapter 15.3: Phosphatidylinositol, Inositol, Phospholipid

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lavendershark790
11 Feb 2018
School
York University
Department
Biology
Course
BIOL 2021
Professor
Patricia Lakin- Thomas

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Document Summary

A gpcr activates a gq protein, which in turn activates an enzyme called phospholipase c-beta. Pip2 (less than 1% of pm lipids) and produces diacylglycerol (dag) in. Pm and inositol 1,4,5-trisphosphate (ip3) in the cytosol (water soluble) Ip3 goes to the er and binds to ip3 receptors called ip3 gated ca2+ release channels: ca2+ that is stored in the er goes into the cytosol. Calcium is very highly regulated in cells because it is toxic. [ca2+] outside = 10-3 m: na/ca2+ exchanger in the pm, atp driven ca2+ pump, ca2+ pump in the er membrane to bring it back in after it releases it. Q: why do cells use ca2+ at an intracellular concentration 10-7 m for signaling rather than. A: large changes in ca2+ concentration will result from influx of fewer ions. Large changes in na+ concentration would be hard to achieve.

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Related Questions

Biochemistry Help!!

1. Which statement is True regarding the Na+ voltage-gated channel in neurons?

a) aspartate residues are parrt of the Voltage-sensing helices

b)similiar to the potassium ion channel, it exisits as a tetramer in the membrane

c) Positivie membrane potentials on the extracellular side will close the channel.

2. Which membrane lipid serves as a reservoir of messenger molecules for signal transduction?

a)Shingomyelin (SM)

b) tarucholic acid (TA)

c) thromboxane A2 (TXA2)

d) Phosphatidylserine (PS)

e) Phosphatidylinositol 4,5-bisphosphate (PIP2)

3) G protein-coupled activation of phospholipase C directly generates which second messenger?

a) inositol-1,4,5-trisphosphate

b)calcium

c) diacylglycerol

d) both diacylglyerol and inositol-1,4,5-trisphosphate

e) both inositol-1,4,5-trisphosphate and calcium

4) Protein Kinase C is allosterically regulated by which second messangers?

a)diacylglyerol (DAG)

b) Calcium (Ca+2)

c) inositol trisphosphate (IP3)

d) both diacylglyerol (DAG) and Calcium (Ca+2)

e) both inositol trisphosphate (IP3) and diacylglyerol (DAG)

5) Phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to form which signaling molecule that triggers Ca+2 release from the endoplasmic reticulum?

a) diacylglycerolphosphate (DAGP)

b) inositol 1,4,5-triphosphate (IP3)

c) diacylglycerol (DAG)

d) inositol 4,5- bisphosphate (IP2)

e) insoitol 5-monophosphate (IP1)