BIOL 3051 Chapter Notes - Chapter 8.1: Vascular Endothelial Growth Factor, Nerve Growth Factor, Epidermal Growth Factor
24 Apr 2020
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Lecture 1 - receptor tyrosine kinase and cell-cell. Enzyme-linked cell surface receptors receptor function of the protein and the enzymatic function are linked within the same polypeptide. Tyrosine kinase associated receptors: associate with intracellular proteins that have tyrosine kinase activity. Receptor serine/threonine kinases: phosphorylate specific serine/ threonine. Receptor guanylyl cyclase"s: directly catalyzes the production of cgmp. Histidine kinase associated receptors: kinase phosphorylates itself on histidine and then transfers the phosphate to a second intracellular signaling protein. Intestinal tissue) you can appreciate that every tissue is composed of multiple cell types in order to form the tissue so there is a need for these cells to talk to each other. Cells must communicate in order to proliferate, differentiate, migrate and maintain a functional state: one cell secretes a growth factor and another cell has the receptor for this growth factor. Critically important during development but also for tissue homeostasis in the adult.
