HIST 3791 Chapter Notes - Chapter 2.8: Supersaturation, Ethambutol, Gout
Document Summary
What is gout: condition in which monosodium (uric acid) crystals deposit in joints, soft tissue (bursa, tendon etc) causing pain, inflammation and disability, usually in the big toe. Infection: stress, trauma, oh, surgery, **medication*, diuretics, levodopa, cyclosporine, cyctoxic drugs, nicotinic drugs, salicylates, ethambutol. When to start uric acid lowering treatments if >2 flares per year if left untreated, the time between attacks gets shorter, and leads to polyarticular issues, and can be associated with fever. Treatment goals: terminate acute attacks, goal is to control inflammation and pain, prevention of acute and chronic gout, goal is to lower uric acid level to prevent precipitation, acute attacks and formation of tophi. Acute gouty arthritis: reduce dietary intake of saturated fats and meats high in purines (shellfish and organ meats) Increase fluid intake and decrease salt (due to risk of gouty nephrolithiasis) Local application of ice, heat may make it worse. Weight loss promote renal excretion of uric acid.
