CAS BB 191 Chapter Notes - Chapter 11: Integral Membrane Protein, Cleavage Furrow, Intermediate Filament
12 Nov 2016
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Membrane proteins: peripheral (loosely attached to one side surface), integral (embeds inside membrane), transmembrane (all the way through, both sides this is a type of integral) Phospholipid membrane permeability small, uncharged, nonpolar molecules (polar can only if small and uncharged) and hydrophobic molecules can freely pass across the membrane. Everything else requires transporter (large, polar, charged molecules). Another way of sayi(cid:374)g i(cid:373)per(cid:373)eable is (cid:862)resista(cid:374)t to(cid:863). Note: peripheral membrane proteins are generally hydrophilic; held in place by h-bonding and electrostatic interaction. Disrupt/detach by changing salt cxn or ph to disrupt these interactions. Integral proteins are hydrophobic; use detergent to destroy membrane and expose these proteins. Channel proteins: provide passageway through membrane for hydrophilic (water-soluble) substances (polar, and charged). **- recognition proteins: such as major-histocompatibility complex on macrophage to distinguish between self and foreign; they are glycoproteins due to oligosaccharides attached. Ion channels: passage of ions across membrane. Called gated channels in nerve and muscle cells, respond to stimuli.
