CAS BI 325 Chapter Notes - Chapter 23: Radial Glial Cell, Cerebral Cortex, Cell Migration
28 Nov 2017
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Dividing cells (neural progenitors that give rise to all neurons and astrocytes of cerebral cortex) Gives rise to most neurons of central nervous system. Early in embryonic development, rgc numbers 100. Divide via symmetrical cell division (later, it is asymmetrical cell division: asymmetrical cell division: one daughter cell migrates and takes position in cortex (will never return, other daughter cell remains in ventricular zone and continues dividing. *in most parts of brain, you have same neurons you were born with. Mature cortical cells classified as glia or neurons. Neurons further classified according to layer they reside, dendritic morphology, axonal connections, and neurotransmitter they use. Depends what genes are transcribed during early development: ultimate fate of migrating daughter cells determined by combo of factors including, age of precursor cell, position within ventricular zone, environment at time of division. Layer where first cells to migrate away from dorsal ventricular zone destined to reside.
