NRSC 4032 Chapter Notes - Chapter 7: Gria2, Enzyme Inhibitor, Gria1
Document Summary
Chapter 7: maintaining the consolidated trace: crick- brought up the fact that synaptic molecules are short lived compared to how long our memories last. Forces that operate to return synapses to their original state: molecular degradation (identified by crick, constitutive, endocytic processes that operate to cycle ampa receptors out of the synaptic region. It self-perpetuates by acting with other proteins to remove. Initial translation of it requires different kinases. the translator repressor protein --> facilitates translation of more pkmz does not have inhibitory domain but has potential binding site for an inhibtory domain --> zip (zeta inhibitory peptide) Zip acts as an inhibitory domain and can return pkmz to it"s natural- non-catalytic state: using zip in hippocampal slides showed no effect in the induction of ltp, but did show prevention in the late phase. Zip reversed potentiated response even after 2 to 5 hours of being applied. >releases glua2 receptors into the psd, potentiating the synapse.
