BIOSC-116 Chapter Notes - Chapter 2: Neuroendocrine Tumor, Carcinoid, Prostaglandin D2
9 Dec 2020
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Document Summary
Pathogenesis and classification of neuroendocrine tumors of lung. Presence of necrosis increased mitosis (>2/10 hpf) large cell neuroendocrine carcinoma. Nesting, palisading, trabecular, insular patterns and rosette-like structures. Carcinoid morphology with > 10 mitosis (large cell neuroendocrine carcinoma) Ectopic acth production can cause cushing"s disease. Carcinoid syndrome when there is widespread metastasis. Pathophysiology of ige mediated allergic reaction mks1b. Immediate: in response to allergen, ige bound to mast cells gets crosslinked and causes mast cell degranulation. This causes the immediate release of histamine (a preformed mediator) Increased mucus production and generation of prostaglandins. Signs and symptoms of allergic rhinitis mks 1d. Caused by inflammation (eosinophils, neutrophils, monocytes, basophils) Sneezing, itching, ear fullness, clicking, or popping. Can generally narrow symptoms down to specific months (seasons may indicate more of a non-allergic sensitivity to barometric pressure changes) Response to treatment is second most important treatment for allergic rhinitis mks1e.
