NBB 302 Chapter Notes - Chapter 7.1: Transient Global Amnesia, Parahippocampal Gyrus, Temporal Lobe

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 302
• Professor: Gillian Hue

Document Summary

R. b -- ischemic episode (reduction of blood to brain) during heart surgery --> anterograde amnesia, mild temporal retrograde amnesia of 1-2 years. Lesion specific to ca1 pyramidal cells of hippocampus. Hippocampus ** for formation of new memories: transient global amnesia (tga): ** trigger by physical exertion of m / emotional stress in f over 50. Amyloid plaques (clump of insoluble protein b/w neuron) Neurofibrillary tangles (protein fiber tangles w/i cortical neurons) Loss of ach cells connecting hippocampus and prefrontal --> loss of new episodic memories. Impaired only if both lesioned --> untrue conclusion that amygdala was ** strx in memory. Zola, squire --lesion on amygdala, entorhinal cortex, or neocortex around parahippocampal gyrus and perirhinal cortex ---> amygdala not part of acquisition system. Visual/auditory/somatosensory --> parahippocampal, perirhinal --> hippocampus --> cortical regions. Selective lesions worsened memory performance in delayed nonmatch-to-sample test: parahippocampal/perirhinal cortices --> sig memory deficits. *** both hippocampal system and associated cortex are * for forming long-term memories ***