MCB 3020 Chapter Notes - Chapter 9: Amantadine, Zidovudine, Amphotericin B
Document Summary
Systemic mycoses: difficult to control and can be fatal, three common drugs. Amphotericin b - binds sterols in membranes. Critical stages in the virus life cycle. Acyclovir, zidovudine etc: drug combinations are more effective, antiprotozoan drugs. Block steps in na synthesis, etc, protein synthesis, folic acid synthesis . Factors influencing antimicrobial drugs: ability of drug to reach site of infection, susceptibility of pathogen to drug, ability of drug to reach concentrations in body that exceed mic of pathogen. Ability of drug to reach site of infection: depends in part on mode of administration. Some drugs destroyed by stomach acid topical. Nonoral routes of administration: drug can be excluded by blood clots or necrotic tissue. Factors influencing ability of drugs to reach concentrations excluding mic: amount administered, rote of administration, speed of uptake, rate of clearance (elimination) from body. Once resistance originates in a population it can be transmitted to other bacteria.
