PCB 3063 Chapter Notes - Chapter 20: Synthetic Biology, Segmental Duplication, Noncoding Dna
26 Apr 2016
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Genomics: field of genetics that tries to understand the content, organization, function, and evolution of genetic information contained in whole genomes: cutting edge of biology- significant contributions to human health/agriculture. Genetic maps: provide a rough approximation of the relative distance between two genes: based on rates of crossing over (recombination, units of percent recombination (cm, important for determining physical maps and genome sequencing, limitations: Detail/very low resolution- in humans, 4,000 cm of info w/ 800,000 bp/cm. Unable to locate every gene due to this very low resolution (detail is limited) Can"t always correlate well with physical distance between genes. Maps based on crossing over, which can vary on different parts of chromosome. When a piece of dna is cut with a restriction enzyme and mapped with gel electrophoresis, the number of restriction sites in the. Dna and the distances between each one can be determined by the number and relative positions of the bands in the gel.
