PCB 4674 Chapter Notes - Chapter 7: Null Hypothesis, Effective Population Size, Neutral Mutation
14 Oct 2016
School
Department
Course
Professor
Document Summary
Mendelian genetics in populations ii: migration, drift, and nonrandom mating. Variation among loci: evidence for functional constraints: rates of molecular evolution vary widely among loci and among organisms and species, genes responsible for most vital cellular functions appear to have the lowest rates of replacement substitutions. Nearly neutral mutations: the neutral mutation rate should vary among species as a function of. At least some protein sequence comparisons in various speciesreveal clocklike change in absolute time, regardless of generation time. Strong negative correlation between average population size and generation time. Species with shorter generation times tend to have larger populations. As generation time goes up, population size goes down and a larger fraction of the mutations that arise are effectively neutral. In extremely large populations, simulations have shown that selection this weak would still be enough to drive an allele to fixation.
