PCB 4674 Chapter Notes - Chapter 6: Motoo Kimura, Neutral Mutation, Genetic Drift

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Mendelian genetics in populations ii: migration, drift, and nonrandom mating. Regardless of population size because they cancel each other out. Advantageous mutations are exceedingly rare and that most alleles of most genes are selectively neutral. For most genes in most populations, the rate of evolution will be equal to the neutral mutation rate: selectionist theory- john gilespie. Advantageous mutations are common enough that they cannot be ignored. For many genes in most populations, the rate of substitution will reflect the action of natural selection on advantageous mutations. It"s not fair to say that most mutations are neutral- advantageous ones can and should be taken into account. Genetic drift versus natural selection: in an ideal population of infinite size, natural selection favoring one allele over others will definitely carry the favored allele to fixation. ***drift does not often significantly impact large population** Summary: genetic drift is a nonadaptive mechanism of evolution.

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