BSC 1010 Chapter Notes - Chapter 15: Archibald Garrod, Frameshift Mutation, Tata Box
8 Feb 2017
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Document Summary
Archibald garrod noted that certain disease among his patients seems to be more prevalent in particular families. Found that some disease were the product of recessive alleles. George beadle & edward tatum provided definitive evidence of garrod"s findings. Deliberately created mutations in chromosomes & verified that they behave in a mendelian fashion in crosses. Nutritional mutations: a mutation affecting a synthetic pathway for a vital compound, such as an amino acid or vitamin. Microorganisms with a nutritional mutation must be grown on medium that supplies the missing nutrient. One-gene/one-polypeptide hypothesis: states that the molecular relationship between genotype & phenotype. Central dogma of molecular biology: is an explanation of the flow of genetic information within a biological system. Information passes in one direction from the gene (dna) to an rna copy (transcription) Rna copy directs the sequential assembly of a chain of amino acids into a protein (translation)
