BISC 2539 Chapter Notes - Chapter 6: Auxotrophy, Hemoglobin, Ornithine

• School: Fordham University
• Department: Biological Sciences
• Course: BISC 2539
• Professor: Varuni Jamburuthugoda

Document Summary

If one allele is a null mutation (produces nonfunctional protein) then the phenotypic mutation is present (heterozygote is still affected: dominant negative: gene product is a homodimeric protein (2 subunits of same type) In the mutant heterozygote, abnormal protein wraps around one or two normal ones and distorts the timer malfunction: difference between haploinsufficiency and dominant negative is the molecular explanation behind the occurence. 6. 2 interaction of genes in pathways: genes act by controlling cellular chemistry. Biosynthetic pathways in neurospora: beadle and tatum studying haploid fungus, neurospora. Gene interaction in other types of pathways: genes interact through pathways i. e. pku in humans. 4: each step requires gene regulation and signal transduction. If progeny are wild type, the recessive mutations must be in different genes the mutations are said to have complemented. If the mutations had been alleles of the same gene, there would have been no complementation.