BIOL 3600 Chapter Notes - Chapter 7: Inbreeding Depression, Molecular Clock, Synonymous Substitution

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Chapter 7 genetic drift: evolution at random. Populations that change in size: population bottleneck ~ severe, temporary reduction in population size, founder event ~ principle that founders of new population carry only fraction of total genetic variation in source population. Genetic drift and natural selection: codon bias ~ nonrandom usage of synonymous codons to encode a given amino acid, positive selection ~ selection for allele that increases fitness. Inbreeding load ~ decline in population"s mean fitness that results from fixation of deleterious mutations by drift. Inbreeding depression ~ reduction, in inbred individuals, of mean value of character (usually one correlated with fitness) relative to offspring of unrelated individuals. The fate of beneficial mutations in large populations. The evolution of differences among species: molecular clocks ~ concept of steady rate of change in dna sequences over time, providing a basis for dating time of divergence of lineages if rate of change can be estimated.

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