BIOL 4015 Chapter Notes - Chapter 1: Angiogenesis, Adenocarcinoma, Telomere
Document Summary
Introduction: 1 in 3 ppl are likely to suffer from cancer during their lifetime, carcinogenesis ~ normal cell is transformed into cancer cell. Characterized by unregulated cell growth and invasion and spread from site of origin: benign ~ not evidence of cancer; don"t spread thorugh body, malignant ~ do not remain encapsulated, show features of invasion, and metastasize. 1. 2 evidence suggests cancer is disease of genome at cellular level. Clonal ~ originating from one cell: cancer theoretically only requires 1 cell of the 1014 cells in your body to be transformed and cause tumor. Environment: where you work and where you relax can contribute to risk of cancer, unprotected exposure to sun exposes skin to uvb radiation alters dna by forming pyrimidine dimers and causing mutations. Smoking: causes lung cancer and is implicated in pancreatic, bladder, kidney, mouth, stomach, and liver cancer, 40% of all cancer deaths since at least 81 carcinogens have been identified in cigarette smoke.
