BIOL 1201 Chapter : February 19th
Document Summary
Circe effect: odysseus" men = negatively charged substrate. Circe effect : siren song = positively charged arginine. At high temperatures biological molecules, such as protein and dna, Regulation of enzyme activity: how are enzymes controlled, can they be turned on and off without destroying it, modulation of activity. Binding of ligands (combine with enzymes) either decreases the activity or increases the activity. Or covalent modification (some are reversible, some are irreversible) Competitive enzyme inhibition: substrate and inhibitor compete for binding to the active site of the enzyme. Inhibitor is structurally similar to the substrate: most apparent at low [substrate concentration] Inhibitor binds at a site away from the substrate binding site: causes a conformational change in the enzyme, not overcome by increasing [substrate] Other site : modulator (activator or inhibitor) binds to a site other than the substrate binding site (active site, causes a conformational change of the enzyme.
