BIOL 4087 Chapter Notes - Chapter 3: Aspartic Acid, Lysine, Threonine
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Consider the peptide:
NH2-GAPAGPAGTGKTETTKDLAKSMALLCWFNCS-COOH
Table I. pK values of some amino acids
amino acid | pK of side chain or terminal group |
---|---|
Alanine (Ala or A) | uncharged |
Arginine (Arg or R) | 12.5 |
Asparagine (Asn or N) | uncharged |
Aspartic acid (Asp or D) | 3.9 |
Cysteine (Cys or C) | 8.3 |
Glutamic acid (Glu or E) | 4.3 |
Glycine (Gly or G) | uncharged |
Histidine (His or H) | 6.0 |
Leucine (Leu or L) | uncharged |
Lysine (Lys or K) | 10.8 |
Phenylalanine (Phe or F) | uncharged |
Serine (Ser or S) | uncharged |
Tryptophan (Trp or W) | uncharged |
Tyrosine (Tyr or Y) | 10.9 |
Valine (Val or V) | uncharged |
peptide N terminus | 7.8 |
peptide C terminus | 3.6 |
Using Table I above, determine the net charge of the peptide at pH9.
(the answer is not -1 or 1)
For the following strand of DNA, use the table below to provide: bases for the complementary mRNA and the associated amino acids. What do you notice about the genetic code for proline in the peptide? How would the loss of the first G or switching that G to a T affect the structure and function of this protein?
DNA: GGC CTA CAA GCC GGA ACA GTT ACC GCG TAA CGA
RNA: ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???
Amino Acid:??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???
(3 Letters)
Genetic Code Table (mRNA)
1st position (5' end) | 2nd position (middle) | 3rd position (3' end) | |||
U | C | A | G | ||
U | Phe F Phe F Leu L Leu L | Ser S Ser S Ser S Ser S | Tyr Y Tyr Y STOP STOP | Cys C Cys C STOP Trp W | U C A G |
C | Leu L Leu L Leu L Leu L | Pro P Pro P Pro P Pro P | His H His H Gln Q Gln Q | Arg R Arg R Arg R Arg R | U C A G |
A | Ile I Ile I Ile I Met M | Thr T Thr T Thr T Thr T | Asn N Asn N Lys K Lys K | Ser S Ser S Arg R Arg R | U C A G |
G | Val V Val V Val V Val V | Ala A Ala A Ala A Ala A | Asp D Asp D Glu E Glu E | Gly G Gly G Gly G Gly G | U C A G |