BIOL 4087 Chapter : KirstieTakeHomeProblemSet
Document Summary
Due tuesday, december 2, 2014: in your own words, summarize the results of this paper. This study tested how inhibition of the akt-mtor-hif-1 pathway prevents the process of trained innate immunity which may protect against infection (cheng, shih-chin, et al. ). Evidence of this trained immunity is seen through the higher consumption of glucose, and production of lactate/nadh. , features of increased glycolysis, using a hif-1 pathway. Trained immunity may also be defined as histone h3 methylation resulting in epigenetic reprogramming and induction by monocyte glycolysis (stunnenberg and. Netea). -glucan, the main cell wall constituent of candida albicans, was used to induce trained innate immune memory in this experiment. Used to train monocytes, b-glucan resulted in a enhance cytokine production when later stimulated by lipopolysaccharide, tlr2 pam3cys ligand, or gram-negative/positive bacteria. This was due to histone methylation and acetylation, inducing promoters specific to -glucan training.
