BIOL 4105 Chapter : Flukes
Document Summary
Egg miracidium sporocyst cercaria schistosomule adult. Definitive host humans, mammals, birds, turtles, fish. Separate sexes, pair up in definitive host & stay paired for life. Cercaria- attracted to skin secretions, penetrates skin via hair follicle, chemicals attracts other cercaria. Schistosomule in lungs: transverses from arteriol to ventral site. Adults migrate to venus plexus, female releases eggs. Schistosomule & adult - camouflage as host self cell. Seas (soluble egg antigens) hydrolytic enzymes, get egg to organ lumen (tissue damaging) Ganulomas around eggs fibrosis + calcification: migratory - asymptomatic, acute katayama fever. Tnf cytokine = vitamin for egg production: chronic - repeated exposure to heavy infections (years) Intestine = chronic diarrhea, maybe bloody due to gut wall fibrosis/ulceration. Liver = portal hypertension (pipe stem fibrosis hepatic portal vein) liver fibrosis, hepatosplenomegaly: very severe chronic. Ascites: japonicum most likely in ectopic to brain, lungs (=underdeveloped children, migratory - asymptomatic, chronic. Portal blood filtration (post rx) - heavy infections.
