BIOL 4124 Chapter : Microbial Pathogens
Document Summary
Transcription- process of making rna using dna as a template, necessary to make proteins: initiation: promoter sites, dna sequence, regulatory proteins, termination: series of uracils followed by inverted repeat or rho. Operons: genes which code for multigene mrna transcripts, many virulence factors are encoded by operon. How does resistance to antibiotics occur: clinical resistance to an antimicrobial agent occurs when minimum inhibitory concentration of the drug for a particular strain of bacteria exceeds that which is capable of being achieved with safety in vivo. By acquisition to extrachromosomal plasmid carrying a resistance gene: 3. Resistance that appears after introdiction of antimicrobial agent into the environment usually results from a selective process, ie the antibiotic selects for survival of those strains possessing a resistance gene. Plasmids: independent, self replicating circular dsdna, carry genes encoding transfer proteins (tra, carry genes which increase survival under certain conditions.
