BIOL 4246 Chapter : 6 25 12
Document Summary
6/25/12: spontaneous mutation rate- probability that a gene will undergo mutation in one generation. Not normally synthesized in normal growth, you only express it during extensive dna damage. It can bind to the b clamp used by pol iii and will compete for the b clamp during damage. Dna pol iii wants the dna in a proper state. You do not want to replicate damaged/broken strands. It is requires for dna pol v to have activity: dna pol v claim to fame is a fantastic translesion polymerase. Can go right over the damage and keep on going: usually puts in an adenine to keep on going, sos mutagenesis, major pol for adaptive genesis is pol iv, encoded by dinbgene. Damage inducible: stress inducible, stationary phase inducible, error prone dna pol, -1 deletions are its favorite. causes common phrase shift mutations.
