COMD 2050 Chapter : Ch 7 Grammar
Document Summary
First messengers activate the g-protein-coupled receptor, which activate a specific g protein. The role of phosphorylation cascades is to activate transcription in the nucleus. Epinephrine (adrenaline) activates a gpcr in liver cells (e. g. , fig. 11. 10, 11. 16, 45. 7 and 45. 9) (after the protein kinase a step in fig 11. 16, activating the enzyme phosphorylase kinase) Calcium activates a phosphorylation cascade in skeletal muscle. Protein kinases are enzymes that catalyze phosphorylation of target. What reactions do protein kinases and phosphatases catalyze? proteins at specific sites. Protein phosphatases catalyze removal of phosphates from phosphorylated proteins. Catalytic contains the enzyme"s active site and a domain that binds atp and a domain that binds the regulatory subunit. **r2c2 dissociates into an r dimer and 2 c monomers, when activated, 2 active subunits are released and c monomers catalyze phosphorylation reactions. 4 subunits (a tetramer 2 regulatory subunits and 2 catalytic subunits)
