KIN 3513 Chapter : Chapter 9 Attention Moodle
15 Mar 2019
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2:17 pm: gap junctions, channels formed between 2 cells, direct electrical and metabolic coupling, common in smooth and cardiac muscle. Inhibiting & releasing hormones into the portal system going to the anterior pituitary: cytokines, peptides or proteins. Involved in cell development, differentiation, and immune response: chemical classification of messengers, chemical class determines mechanism of transport and mechanism of action on target cell. Lipophobic/hydrophilic = can dissolve in plasma or isf: amino acid messengers, all function as neurotransmitters, glutamate, glycine, gaba. Lipophobic: amine messengers, derived from amino acids and contain amine group, catecholamines - derived from tyrosine, dopamine, norepinephrine, epinephrine. Serotonin (5 dht) - derived from tryptophan: histamine, thyroid hormones. Lipophobic (except thyroid hormones: steroid messengers, derived from cholesterol, all hormones. Lipophilic: all need protein transporters: synthesis and release of chemical messengers. Lipophilic messengers - diffusion: released upon synthesis, regulate release by regulating rate of synthesis.
