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MICR 470 Chapter Notes - Chapter 2: Natural Killer Cell, Innate Immune System, Adaptive Immune System

60 views12 pages
tealcamel62
3 Sep 2018
School
NDSU
Department
Microbiology
Course
MICR 470
Professor
Glenn Dorsam

For unlimited access to Textbook Notes, a Class+ subscription is required.

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Document Summary

For structures shared by classes of microbes (pathogen-associated mole damaged cells (damage-associated molecular patterns) Encoded in germline; limited diversity (pattern recognition receptors) molecular patterns) or ecule. Nonclonal: identical receptors on all cells of the same lineage. Toll-like receptors (tlrs): are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. cells, that recognize structurally conserved molecules derived from microbes. Signals generated by engagement of tlrs activate transcription factors that stimulate expression of genes encoding cytokines, enzymes, and other proteins involved in the antimicrobial function of activated phagocytes and other cells. Nod-like receptors (nlrs): are a large family of cytosolic receptors that sense. Nod-1 and nod-2 are cytostolic proteins containing n-terminal card (caspase related) domains specific for peptidoglycans activate nf-kb transcription factor.

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