01:447:380 Chapter 16: Multifactorial Traits and Diseases and Quantitative Genetics
29 May 2019
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Document Summary
Genetics 380: multifactorial traits and diseases and quantitative genetics. Genetic, epigenetic and nongenetic factors interact to influence phenotypes. Most traits and diseases are multifactorial (aka complex) traits and diseases. Expression of most traits is controlled by the interaction of several genes as well as multiple nongenetic factors. Epigenetic factors influence gene activity, and therefore phenotypes as well. This also allows for the occurrence of phenocopies phenotypes that resemble the effects of a gene mutation but have arisen solely from nongenetic factors (ex. lung cancer in a chronic chain- smoker). Ex. good nutrition can increase the height of an individual with a given genotype, to equal the height of an individual with a better genotype but poorer nutrition. There is variability within individuals with the same genotype. The more genotypes in the population, the greater the variance in the population. Quantitative genetics tries to determine why individuals are different from.
