MIC 463 Chapter : Virology Exam 2 Study Guide
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Please note: for each of the following, know the mechanisms and the distinguishing characteristics of replication and expression discussed in class, and examples of specific viruses in the class. Some specifics to know (in addition to the overall infection/expression/replication mechanisms and locations, and whether host or viral replicase used as discussed in class) are listed. For replication mechanisms, study the figures in the textbook. + strand rna viruses: picornaviridae, small, simple, naked, icosahedral, 60 x 4 different proteins (240) total in capsid (vp1-4, 7000-8500 nucleotides long, polio 3" polya tail, no 5" cap. Instead vpg attached to 5" end vpg small protein. The 5" terminus of the poliovirus genome has the viral protein vpg attached to it rather than the 7-methyl- guanosine cap. When translation of a eukaryotic mrna begins, the cap is recognized by a cap-binding complex of cellular proteins called eif4g.