BIOL 180 Chapter Notes - Chapter 16: Nonsense Mutation, Rubik'S Revenge, Tryptophan

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15 Apr 2016
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BIOL 180 Full Course Notes
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How does a gene specify the production of a protein: part of answer lays in molecular structure of the gene. These bases are connected in linear sequence by sugar-phosphate backbone. Dna molecule = two strands wound to double helix, held together by hydrogen bonds between complementary base pairs a-t & g-c. Appears extremely unlikely that dna directly catalyzed the reactions that produce proteins. Its shape was too regular to say it could bind a wide variety of substrate molecules and lower activation energy for chemical reactions. Crick proposed sequence of bases in dna might act as a code: his idea: dna was only an information storage molecule. Instructions it contained would have to be read and translated into proteins. Crick proposed that different combos of bases could specify the 20 amino acids just like morse code can specify the letters of the alphabet. Link between dna as information repository and proteins as cellular machines is indirect.

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