LIFESCI 1 Chapter Notes - Chapter 6: Integrin, Glycolipid
Document Summary
Tight junctions prevent substances from moving through the spaces between cells. For example, cells lining the bladder have tight junctions so urine cannot leak out into the body cavity. Another important function of tight junctions is to maintain distinct faces of a cell within a tissue by restricting the migration of membrane proteins over the cell surface from one face to the other. The binding of integrin to the extracellular matrix is noncovalent and reversible. when a cell moves its location within a tissue or organism, one side of the cell detaches from the extracellular matrix while the other side extends in the direction of movement, forming new attachments in that direction. the integrin at the back of the cell (away from the direction of movement) is brought into the cytoplasm by endocytosis so that it can be recycled and used for new attachments at the front of the cell .
