MCD BIO 165A Chapter Notes - Chapter signaling: Netrin, Signal Transduction, Morphogenesis

• School: UCLA
• Department: Molecular, Cell, and Developmental Biology
• Course: MCD BIO 165A
• Professor: arispe

Document Summary

General concepts: cell signaling enables communication between cells, facilitates morphogenesis (organization of tissues) Integration of tissues and organs e. g. insulin secretion (intestine conveys information to pancrease: adaptation of cells to environmental changes. Cold -> more cholesterol -> fo(cid:396)tifies (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e so that (cid:272)ell does(cid:374)"t (cid:271)u(cid:396)st du(cid:396)i(cid:374)g crystallization. Mechanism: ligand binds receptors -> intracellular signaling, shape of receptor & ligand has specificity (molecular conformation) Interaction changes conformation of intracellular domain of receptor -> receptor interacts with other molecules in cytosol. Does(cid:374)"t happe(cid:374) without (cid:272)o(cid:374)fo(cid:396)(cid:373)atio(cid:374) (cid:272)ha(cid:374)ge: an example. Binds to ligand -> 2 receptors together (dimerization) & intracellular domain changes: shape & phosphorylation. Series of modification: signaling cascade: every reaction of a kinase associated with reverse reaction mediated by phosphatase, number of intracellular molecules interacting with receptors is a rate limiting step in signal transduction. Consequences: change in cell number (dividing or death, change in cell shape.