PHYSCI 111A Chapter Notes - Chapter 6: Muscle Fatigue, Neuromuscular Junction, Specific Strength
18 Sep 2016
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Muscle fatigue: loss of force or power producing capacity in response to contractile activity. Muscular endurance: duration that a given target force can be maintained. Human fatigue fall of maximal force or power relative to an individuals baseline. Good for making comparisons because looking at rel. drop in peak force or power eliminates factors of muscle size and strength. Goal of review: provide an integrative perspective that suggests how changes in the senescent neuromuscular system may act together to increase its ability to resist fatigue under some conditions. Determining the mechanisms of muscle fatigue in vivo: working model of the potential sites of failure that can result in fatigue. Good integrates measures of central and peripheral activation, intracellular energy metabolism and contractile function (in vivo and noninvasively) Fall in m-wave amplitude suggests loss of excitability at the neuromuscular junction or along the muscle membrane. Typically does not play an important role in fatigue during voluntary contractions in humans.
