AH 3121 Chapter Notes - Chapter 5: Macrophage, Natural Killer Cell, Pleiotropy
Document Summary
Prevent transplant/graft rejection: inhibits activity of calcineurin. One of the enzymes that becomes active in the signaling pathways. Cytokines: intracellular messengers, group of proteins involved in immunity and inflammation. Secreted soluble factors, in picomolar amounts: bind to receptors on target cells to produce biologic effects, interleukins. Produced by wbcs to act on wbcs s: general properties of cytokines. Tcr signal and costimulation induce cytokine gene transcription. Usually acts on same call that produces the cytokine (autocrine) or nearby cells (paracrine) T cell activation induces expression of both cytokines and high-affinity receptors for cytokines. Many different cell types may express receptors for a particular cytokine. Redundancy: multiple cytokines may share the same or similar biological activities. Many cytokines use same conserved signaling pathways: biological actions of selected t cell cytokines. Active in survival, proliferation and differentiation of effector and regulatory t cells. Cd4+ and cd8+ t cells are cellular sources. Avery welch ah 3121 immunology week 4 chapter 5 notes 9/22/15-/9/24/15.
