AH 3121 Chapter Notes - Chapter 10: Dna Virus, Hepatitis B Virus, Metastasis
Document Summary
Malignant cells present in blood: lymphoma involves solid lymphoid tumors. Malignant cells are present in lymph node and sometimes in other tissues: myeloma involves bone marrow. Multiple myeloma results from an abnormal proliferation of plasma cells. Clone of malignant plasma cells produces monoclonal immunoglobulin: malignant cells have distinct morphologies, t cell malignancies are rare because these cells are not infected by ebv and do not undergo somatic hypermutation and are vulnerable to apoptosis. Contribute positively to initiation and execution of cell division. Encode proteins that prevent unwanted proliferation of mutant cells. Produces protein in response to dna damage. + normally leads to apoptosis of the mutant cell. Avery welch ah 3121 immunology week 10 chapter 10 notes 11/3/15 & 11/5/15. Tp53 mutations are seen in over 50% of all cancers. + most common gene abnormality in human cancer. Genetic factors contributing to cancer: germline mutation in one copy of a tumor suppressor gene protein is still produced, li-fraumeni syndrome.
